A. Alhefdhi1, S. AlNefaie1, O. Almalik1 1King Faisal Specialist Hospital and Research Center (KFSH), and AlFaisal University,Breast And Endocrine Surgery/General Surgery,Riyadh, RIYADH, Saudi Arabia
Introduction: Breast cancer accounts for 26% of the cancers in Saudi Arabia, with a median age of 49 years at diagnosis. However, no published literature about treating breast cancer in a young Saudi population.The aim of this study is to explore the characteristic features of breast cancer in Saudi patients 40 years of age or younger.
Methods: A five-year retrospective review conducted, including all patients diagnosed with breast cancer and operated at a single tertiary hospital.
Results:A total of 1026 were identified. Among them, 230 cases (22%) meet our inclusion criteria with a mean age of 34±5 years. The majority had IDC (85.7%), followed by DCIS in (6.5%), malignant phylloids in (3.1%), ILC in (1.7%), metaplastic carcinoma in (1.3%), intracystic papillary carcinoma in (0.9%), (0.4%) of borderline phylloid, and (0.4%) of Angiosarcoma. Only (14%) found to have a positive family history of breast cancer, and (15%) found to have metastatic disease at diagnosis. The recurrence rate was (17.4%). Moreover, the majority underwent lumpectomy with/without SLND/ALND (38%), followed by SSM (22%), simple mastectomy with/without SLNB (13%), MRM (10%), palliative surgery (6.5%), nipple sparing mastectomy (4.5%), wire localization lumpectomy (4%), then bilateral surgery (3%). Among the patients with IDC (51.3%) had grade 3 cancer, (70%) had a positive ER, (53%) had a positive PR, (26%) had positive Her-2, (24%) had triple negative.
Conclusion:Our data suggested that 1/4th of breast cancer cases are 40 years or younger. Further studies are needed to confirm our findings and to exclude possible genetic mutations.